{"product_id":"the-organic-chemistry-of-drug-design-and-drug-action-9780123820303","title":"The Organic Chemistry of Drug Design and Drug Action","description":"\u003cp\u003eThe Organic Chemistry of Drug Design and Drug Action  Third Edition  represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action  which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters  including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters  including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections  virtual screening  and computational methods  as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds  fragment-based lead discovery  and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions  cation- and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition  the epidermal growth factor receptor tyrosine kinase inhibitor  erlotinib and Abelson kinase inhibitor  imatinib for transition state analogue inhibition  the purine nucleoside phosphorylase inhibitors  forodesine and DADMe-ImmH  as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow  tight-binding inhibition  the dipeptidyl peptidase-4 inhibitor  saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition  with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibodydrug conjugates\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":45651359236149,"sku":"ByrdShop_0123820308","price":78.46,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0627\/8139\/0901\/files\/9780123820303.jpg?v=1781834131","url":"https:\/\/atxbooks.com\/products\/the-organic-chemistry-of-drug-design-and-drug-action-9780123820303","provider":"ATX Books","version":"1.0","type":"link"}