Practical Process Research and Development

About this book

This book provides a comprehensive step-by-step approach to organic process research and development in the pharmaceutical fine chemical and agricultural chemical industries. Process R&D describes the steps taken following synthesis and evaluation to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on step-by-step approaches to solving process development problems including route reagent and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers managers and graduate students. Provides insights into generating rugged practical cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route reagent and solvent selection development of reaction conditions workup crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes