Translational Neuroscience: Toward New Therapies (Strngmann Forum Reports)

About this book

Experts from academia and industry discuss how to create a new more effective translational neuroscience drawing on novel technology and recent discoveries. Today translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics stem cell biology and neuroscience emerged to offer new possibilities. In this volume experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscienceone informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Bckers Thomas Bourgeron Karl Broich Nils Brose Bruce N. Cuthbert Ilka Diester Gl Dlen Guoping Feng Richard Frackowiak Raquel E. Gur Stephan Heckers Franz Hefti David M. Holtzman Steven E. Hyman Nancy Ip Cynthia Joyce Tobias Kaiser Edward H. Koo Walter J. Koroshetz Katja S. Kroker Robert C. Malenka Isabelle Mansuy Eliezer Masliah Yuan Mei Andreas Meyer-Lindenberg Lennart Mucke Pierluigi Nicotera Karoly Nikolich Michael J. Owen Menelas N. Pangalos Alvaro Pascual-Leone Joel S. Perlmutter Trevor W. Robbins Lee L. Rubin Akira Sawa Mareike Schnaars Bernd Sommer Maria Grazia Spillantini Laura Spinney Matthew W. State Marius Wernig